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Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia

Zammit, Stanley ORCID:, Lewis, G., Thapar, Anita ORCID:, Owen, R., Jones, G., Jones, S., Sanders, R., Milham, C., Mahdi, A., O'Donovan, Michael Conlon ORCID: and Owen, Michael John ORCID: 2006. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. Journal of Psychiatric Research 40 (7) , pp. 622-626. 10.1016/j.jpsychires.2005.05.006

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BACKGROUND: Phenotypic differences between parent-offspring trios and non-trios have been reported for various psychiatric disorders, and it has been suggested that this may make comparisons of case-control and family-based results for gene-disease association studies inappropriate. AIMS: To compare phenotypes between trios and non-trios with schizophrenia, and explore possible reasons for differences observed. METHOD: Phenotypes were compared between trios (n=75) and non-trios (n=424) collected as part of a case-control study. RESULTS: Differences were observed for most phenotypes investigated, although all were eliminated after adjusting for confounding. CONCLUSIONS: Confounding, genetic heterogeneity or selection bias could result in differences in case-control and family-based results. However as we discuss, where adequately designed case-control studies are used, gene-disease association results would be incomparable between family-based and case-control studies only if genetic heterogeneity was present. These results do not support the presence of such genetic heterogeneity in schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0022-3956
Last Modified: 17 Nov 2022 13:27

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