Tomassini, Valentina  ORCID: https://orcid.org/0000-0002-7368-6280, Onesti, E., Mainero, C., Giugni, E., Paolillo, A., Salvetti, M., Nicoletti, F. and Pozzilli, C.
2005.
Sex hormones modulate brain damage in multiple sclerosis: MRI evidence.
Journal of Neurology, Neurosurgery & Psychiatry
76
(2)
, pp. 272-275.
10.1136/jnnp.2003.033324
|
Abstract
BACKGROUND: Sex related differences in the course and severity of multiple sclerosis (MS) could be mediated by the sex hormones. OBJECTIVE: To investigate the relation between serum sex hormone concentrations and characteristics of tissue damage on conventional magnetic resonance imaging (MRI) in men and women suffering from relapsing-remitting MS. RESULTS: Serum testosterone was significantly lower in women with MS than in controls. The lowest levels were found in women with a greater number of gadolinium enhancing lesions. A positive correlation was observed between testosterone concentrations and both tissue damage on MRI and clinical disability. In men, there was a positive correlation between oestradiol concentrations and brain damage. CONCLUSIONS: The hormone related modulation of pathological changes supports the hypothesis that sex hormones play a role in the inflammation, damage, and repair mechanisms typical of MS.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | BMJ Publishing Group |
| ISSN: | 0022-3050 |
| Last Modified: | 31 Oct 2022 10:05 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/83590 |
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