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Sex hormones modulate brain damage in multiple sclerosis: MRI evidence

Tomassini, Valentina ORCID:, Onesti, E., Mainero, C., Giugni, E., Paolillo, A., Salvetti, M., Nicoletti, F. and Pozzilli, C. 2005. Sex hormones modulate brain damage in multiple sclerosis: MRI evidence. Journal of Neurology, Neurosurgery & Psychiatry 76 (2) , pp. 272-275. 10.1136/jnnp.2003.033324

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BACKGROUND: Sex related differences in the course and severity of multiple sclerosis (MS) could be mediated by the sex hormones. OBJECTIVE: To investigate the relation between serum sex hormone concentrations and characteristics of tissue damage on conventional magnetic resonance imaging (MRI) in men and women suffering from relapsing-remitting MS. RESULTS: Serum testosterone was significantly lower in women with MS than in controls. The lowest levels were found in women with a greater number of gadolinium enhancing lesions. A positive correlation was observed between testosterone concentrations and both tissue damage on MRI and clinical disability. In men, there was a positive correlation between oestradiol concentrations and brain damage. CONCLUSIONS: The hormone related modulation of pathological changes supports the hypothesis that sex hormones play a role in the inflammation, damage, and repair mechanisms typical of MS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: BMJ Publishing Group
ISSN: 0022-3050
Last Modified: 31 Oct 2022 10:05

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