IGF1, growth pathway polymorphisms and schizophrenia: A pooling study

Gunnell, D., Lewis, S., Wilkinson, J., Georgieva, Lyudmila, Davey, G. Smith, Day, I.N.M., Holly, J.M.P., O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 and Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211 2007. IGF1, growth pathway polymorphisms and schizophrenia: A pooling study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (1) , pp. 117-120. 10.1002/ajmg.b.30396

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Abstract

It has been hypothesized that insulin-like growth factors (IGFs) and components of the growth-hormone (GH)-IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH-IGF system--the IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein-3 (IGFBP3). The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in IGF1 nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	1552-4841
Last Modified:	17 Dec 2023 16:15
URI:	https://orca.cardiff.ac.uk/id/eprint/83797

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