Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience

Ghosh, Saurabh, Babron, Marie-Claude, Group 10, Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958 and Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412 2007. Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience. Genetic Epidemiology 31 (S1) , S86-S95. 10.1002/gepi.20284

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Abstract

The group that formed on the theme of linkage analyses of rheumatoid arthritis RA and related phenotypes (Group 10) in the Genetic Analysis Workshop 15 comprised 18 sets of investigators. Two data sets were available: one was a real set provided by the North American Rheumatoid Arthritis Consortium and collaborators in Canada, France (European Consortium Of Rheumatoid Arthritis Families) and the UK; the other was a simulated data set modelled after the real data set. Whereas a majority of the investigators analyzed the RA affection status as a binary phenotype, a few contributions considered data on correlated quantitative traits such as anti-cyclic citrullinated peptide and rheumatoid factor-immunoglobulin M. The different investigators applied a wide spectrum of linkage methods. As expected, most methods could identify the human leukocyfeantigen region on chromosome 6 as a major genetic factor for RA. In addition, some novel chromosomal regions provided significant evidence of linkage in multiple contributions in the group. In this report, we discuss the different strategies explored by the different investigators with the common goal of improving the power to detect linkage.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Marian Hamshere and Peter Holmans are members of Group 10
Publisher:	Wiley
ISSN:	0741-0395
Last Modified:	31 Oct 2022 10:08
URI:	https://orca.cardiff.ac.uk/id/eprint/83799

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