Marlow, Gareth  ORCID: https://orcid.org/0000-0002-7608-9086, Han, Dug Yeo, Triggs, Christopher M. and Ferguson, Lynnette R.
2015.
Food intolerance: associations with the rs12212067 polymorphism of FOXO3 in Crohn's Disease patients in New Zealand.
Journal of Nutrigenetics and Nutrigenomics
8
(2)
, pp. 70-80.
10.1159/000435783
|
Abstract
Background: Diet is known to play a major role in Crohn's disease (CD). It has also been reported that the minor G allele from the rs12212067 polymorphism (T>G) in FOXO3 is associated with milder CD. The aim of this study was to investigate the association between the rs12212067 polymorphism and food intolerances for a total of 253 foods. Methods: Tolerances and intolerances were recorded on a self-reported dietary questionnaire. Each food was scored on a 5-point ordinal scale: beneficial effects as ‘+ +' or ‘+', adverse effects as ‘- -' or ‘-', and ‘makes no difference' as ‘='. Dietary and genotype data were available for a total of 283 CD patients. Results: We identified 17 foods with beneficial effects in our study which were significantly associated with the G allele of the FOXO3 rs12212067 polymorphism. Of these, sweet potatoes had the highest reported frequency of beneficial responses. We also identified 4 foods with detrimental effects in more than 25% of our study population. These were mustard, wasabi, and raw and cooked tomatoes, which again were significantly associated with the G allele in FOXO3. Conclusions: There was strong evidence that adverse effects of mustard, wasabi, and raw and cooked tomatoes were significantly associated with the G allele of FOXO3 and that these foods should be avoided by people carrying this allele.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Karger |
| ISSN: | 1661-6499 |
| Date of Acceptance: | 4 June 2015 |
| Last Modified: | 31 Oct 2022 10:09 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/83868 |
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