Comparison of galactomannan enzyme immunoassay performance levels when testing serum and plasma samples

White, P., Jones, T., Whittle, K., Watkins, Joanne and Barnes, Rosemary Ann 2013. Comparison of galactomannan enzyme immunoassay performance levels when testing serum and plasma samples. Clinical and Vaccine Immunology 20 (4) , pp. 636-638. 10.1128/CVI.00730-12

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Abstract

Diagnostic galactomannan (GM) enzyme immunoassay (EIA) testing is formally validated only for serum, though in practice, plasma is occasionally tested. It is assumed, but not confirmed, that results will be comparable to those for serum. GM EIA when testing plasma was evaluated, providing sensitivity (85.7%) and specificity (85.4%) comparable to those for serum. Plasma index values were higher than those for serum; if plasma GM EIA were used to define probable cases, four additional cases would have been diagnosed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Antigens, Fungal; Aspergillosis; Clinical Laboratory Techniques; Humans; Immunoenzyme Techniques; Mannans; Plasma; Sensitivity and Specificity; Serum
Publisher:	American Society for Microbiology
ISSN:	1556-6811
Date of Acceptance:	2 February 2013
Last Modified:	04 Jun 2017 08:44
URI:	https://orca.cardiff.ac.uk/id/eprint/83934

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