Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology

Ashbee, H. Ruth, Barnes, Rosemary Ann, Johnson, Elizabeth M., Richardson, Malcolm D., Gorton, Rebecca and Hope, William W. 2014. Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology. Journal of Antimicrobial Chemotherapy 69 (5) , pp. 1162-1176. 10.1093/jac/dkt508

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Abstract

The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. TDM may increase the probability of a successful outcome, prevent drug-related toxicity and potentially prevent the emergence of antifungal drug resistance. Much of the evidence that supports TDM is circumstantial. This document reviews the available literature and provides a series of recommendations for TDM of antifungal agents.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Oxford University Press
ISSN:	0305-7453
Date of Acceptance:	29 December 2013
Last Modified:	31 May 2019 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/84241

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