Drosophila melanogaster P1 genomic clone DS05563 contains the chaperonin-encoding gene Cctg

Walkley, Neal and Malik, Afshan 1996. Drosophila melanogaster P1 genomic clone DS05563 contains the chaperonin-encoding gene Cctg. Gene 171 (2) , pp. 221-223. 10.1016/0378-1119(96)00097-2

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Abstract

We report the sequence analysis of a Drosophila melanogaster (Dm) P1 genomic clone (DS05563) which contains the γ-chaperonin-encoding gene, Cctg. The (Hs) Cctg orthologue was found to share strong sequence identity with a 1603-bp region of DS05563, suggesting that Dm Cctg is located within this region. Detailed analysis has shown that Dm Cctg comprises four exons and is interrupted by three introns of 55, 85 and 66 bp. Dm Cctg encodes a predicted peptide of 545 amino acids (aa) (approx. 60 kDa). The predicted Dm CCTγ aa sequence shares a high degree of sequence identity with γ-orthologues from human (70%), mouse (70%), protozoa (60%) and yeast (60%), and also contains domains found in other chaperonins including bacterial GroEL, mitochondrial Hsp60 and plant Rubisco large subunit-binding protein. These data support the conclusion that the DS05563 clone contains the Dm Cctg gene.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	Elsevier
ISSN:	0378-1119
Last Modified:	10 Oct 2017 16:52
URI:	https://orca.cardiff.ac.uk/id/eprint/84513

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