Phenotypic heterogeneity in Hidradenitis Suppurativa (Acne Inversa): classification is an essential step toward personalized therapy

Ingram, John R. ORCID: https://orcid.org/0000-0002-5257-1142 and Piguet, Vincent 2013. Phenotypic heterogeneity in Hidradenitis Suppurativa (Acne Inversa): classification is an essential step toward personalized therapy. Journal of Investigative Dermatology 133 (6) , pp. 1453-1456. 10.1038/jid.2012.476

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Abstract

Awareness is increasing that there is phenotypic heterogeneity within the hidradenitis suppurativa (HS) disease spectrum. However, the few randomized HS trials that are available have not distinguished between the subtypes of the disease. In this issue, Canoui-Poitrine et al. used latent class (LC) analysis of the largest HS cohort described to date to generate three phenotypic subtypes. LC 1 correlates with "typical" European HS, mainly involving the axilla, groin, and, in women, the inframammary region. "Atypical" HS, which may be linked to γ-secretase gene mutations, was subdivided further into LC2 and LC3 subtypes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RL Dermatology
Additional Information:	Published under an Elsevier User License: https://www.elsevier.com/about/company-information/policies/open-access-licenses/elsevier-user-license
Publisher:	Elsevier
Date of First Compliant Deposit:	30 March 2016
Last Modified:	17 Mar 2024 17:03
URI:	https://orca.cardiff.ac.uk/id/eprint/84976

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