Update on a new controversy in endocrinology: isolated maternal hypothyroxinemia

Furnica, R. M., Lazarus, John Henry, Gruson, D. and Daumerie, C. 2015. Update on a new controversy in endocrinology: isolated maternal hypothyroxinemia. Journal of Endocrinological Investigation 38 (2) , pp. 117-123. 10.1007/s40618-014-0203-5

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Abstract

Isolated hypothyroxinemia (IH) is defined as a thyroxine level in the lower 5th (severe IH) or 10th percentile (mild IH) of the pregnancy-related reference range and a normal TSH. The etiology of IH remains unknown. This review aims to evaluate the biochemical criteria used to define IH in different published studies and to discuss potential maternal as well as fetal outcomes and whether treatment during early pregnancy can prevent the eventual adverse effects. For the current literature a better standardization of free thyroxine assays is needed, as well as the use of appropriated trimester-specific reference intervals for thyroid function tests. Today no study demonstrates a benefit from treating early pregnant IH women on perinatal and fetal outcomes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Hypothyroxinemia, FreeT4 assays, Perinatal outcome, Neurodevelopmental delay
Publisher:	Springer
ISSN:	1720-8386
Date of Acceptance:	19 October 2014
Last Modified:	12 Jun 2019 09:14
URI:	https://orca.cardiff.ac.uk/id/eprint/85358

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