Structural correlation between collagen VI microfibrils and collagen VI banded aggregates

Knupp, Carlo ORCID: https://orcid.org/0000-0001-9127-2252, Pinali, Christian, Munro, Peter M., Gruber, Helen E., Sherratt, Michael J., Baldock, Clair and Squire, John M. 2006. Structural correlation between collagen VI microfibrils and collagen VI banded aggregates. Journal of Structural Biology 154 (3) , pp. 312-326. 10.1016/j.jsb.2006.03.023

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Abstract

Collagen VI is a component of the extracellular matrix that is able to form structural links with cells. Collagen VI monomers cross-link into tetramers that come together to form long molecular chains known as microfibrils. Collagen VI tetramers are also the most likely candidates for the formation of banded aggregates with an axial periodicity of about 105 nm that are seen in the retinas of people suffering from age-related macular degeneration and Sorsby’s fundus dystrophy, in the vitreous of patients with full thickness macular holes and in the intervertebral discs of normal individuals. Here, a protocol is developed to carry out a structural comparison between the microfibrils, which are known to be made of collagen VI tetramers, and the banded aggregates. The comparison shows that the banded aggregates are easily explained as being a lateral assembly of microfibrils, thus supporting the hypothesis that they too are made of collagen VI. Understanding the role played by the collagen VI aggregates in normal and pathological conditions will help to throw light on the pathologies with which they are associated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Uncontrolled Keywords:	Type VI collagen; Beaded filaments; Network-forming collagen; Long spacing collagen; Luse bodies; Age-related macular degeneration; Sorsby’s fundus dystrophy; Intervertebral disc
ISSN:	10478477
Last Modified:	17 Oct 2022 08:43
URI:	https://orca.cardiff.ac.uk/id/eprint/856

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