| Caley, Andrew, Evans, Mererid, Powell, Ned, Paleri, Vinidh, Tomkinson, Alun, Urbano, Teresa Guerrero, Jay, Amrita, Robinson, Max and Thavaraj, Selvam 2014. Multicentric human papillomavirus-associated head and neck squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 37 (2) , pp. 202-208. 10.1002/hed.23584 |
Abstract
Background The purpose of this study was to present the clinicopathological features of a series of patients with human papillomavirus (HPV)-associated head and neck second primary tumors. Methods Patients with HPV-associated head and neck second primary tumors from 3 centers were identified. HPV infection was evaluated using p16 by immunohistochemistry (IHC), high-risk HPV DNA by in situ hybridization (ISH), and HPV genotyping by DNA polymerase chain reaction (PCR) enzyme immunoassay (EIA). Results Eleven patients were identified: 5 with synchronous and 6 with metachronous HPV-positive second primary tumors, the latter demonstrating a mean time interval of 5 years. There were 13 second primary tumors: 11 oropharyngeal, 1 nasopharyngeal, and 1 floor of the mouth. Nine of 10 genotyped patients harbored HPV-16, and 1 patient had HPV-33 in 3 synchronous tumors. Conclusion HPV-associated second primary tumors may present as synchronous and/or metachronous lesions and can arise outside the oropharynx after prolonged intervals. Further work is necessary to identify patients at risk and to elucidate the mechanisms of HPV-associated head and neck second primary tumors.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | second primary tumor;human papillomavirus;head and neck squamous cell carcinoma;multicentric;pharyngeal |
| Publisher: | Wiley |
| ISSN: | 1043-3074 |
| Date of Acceptance: | 18 December 2013 |
| Last Modified: | 17 Nov 2022 14:59 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/85791 |
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