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Methods to determine the interactions of micro- and nanoparticles with mucus

Grießinger, Julia, Dünnhaupt, Sarah, Cattoz, Beatrice, Griffiths, Peter, Oh, Sejin, Gómez, Salvador Borrós i, Wilcox, Matthew, Pearson, Jeffrey, Gumbleton, Mark, Abdulkarim, Muthanna, Pereira de Sousa, Irene and Bernkop-Schnürch, Andreas 2015. Methods to determine the interactions of micro- and nanoparticles with mucus. European Journal of Pharmaceutics and Biopharmaceutics 96 , pp. 464-476. 10.1016/j.ejpb.2015.01.005

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The present review provides an overview of methods and techniques for studying interactions of micro- and nanoparticulate drug delivery system with mucus. Nanocarriers trapped by mucus are featuring a change in particle size and zeta potential that can be utilized to predict their mucus permeation behavior. Furthermore, interactions between nanoparticulate drug delivery systems and mucus layer modify the viscoelasticity of mucus which can be detected via rheological studies and quartz crystal microbalance with dissipation monitoring (QCM-D) analysis. Having a closer look at molecular interactions between drug carrier and mucus small-angle neutron scattering (SANS) is an appropriate analysis technique. Moreover, different methods to determine particle diffusion in mucus such as the newly established Transwell diffusion system, rotating silicone tube technique, multiple-particle tracking (MPT) and diffusion NMR are summarized within this review. The explanations and discussed pros and cons of collated methods and techniques should provide a good starting point for all those looking forward to move in this interesting field.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Elsevier
ISSN: 0939-6411
Funders: European Commission (EC). Seventh Framework Program of the EC (Grant Agreement Number 280761).
Date of First Compliant Deposit: 10 May 2016
Date of Acceptance: 7 January 2015
Last Modified: 04 Jun 2017 08:50

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