Effects of combined vitamin D - Calcium supplements on the cardiovascular system: Should we be cautious?

Challoumas, Dimitrios, Stavrou, Antonio, Pericleous, Agamemnon and Dimitrakakis, Georgios 2015. Effects of combined vitamin D - Calcium supplements on the cardiovascular system: Should we be cautious? Atherosclerosis 238 (2) , pp. 388-398. 10.1016/j.atherosclerosis.2014.12.050

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Abstract

Despite the growing body of evidence on the potential effects of calcium and vitamin D as monotherapies on different cardiovascular (CV) parameters, the combined supplementation with calcium and vitamin D (CaD), which is most frequently encountered in clinical practice, has not received the attention it deserves. A literature search was conducted via EMBASE and Medline and identified 14 randomised controlled trials (RCTs) and 2 meta-analyses reporting on effects of combined supplementation with CaD on CV events, CV death, blood pressure, lipids, glucose metabolism and weight. Overall, the existing evidence does not support beneficial properties of supplementation with CaD on the CV system, nor does it suggest that a re-appraisal of the use of CaD is necessary due to adverse effects, although increased risk of CV events has been reported by some authors. The guidelines for the use of CaD supplementation need not change until well-conducted RCTs that have CV effects as primary outcomes and adjust for major confounders indicate otherwise.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Calcium; Vitamin D; Supplements; Effects; Cardiovascular; Blood pressure; Weight; Diabetes; Lipids; Events
Publisher:	Elsevier
ISSN:	0021-9150
Date of Acceptance:	21 December 2014
Last Modified:	13 Jun 2019 10:37
URI:	https://orca.cardiff.ac.uk/id/eprint/86275

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