The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level

Connelly, William, Laing, Michael ORCID: https://orcid.org/0000-0002-9669-1031, Errington, Adam C. ORCID: https://orcid.org/0000-0002-2171-389X and Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 2016. The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. Frontiers in Neural Circuits 9 , 89. 10.3389/fncir.2015.00089

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Abstract

In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiological parameters, we show that the thalamus behaves akin to a low pass filter. Specifically, as individual cells in the thalamus rely on consistent drive to spike, stimuli that is rapidly and continuously changing over time such that it activates sensory cells with different receptive fields are unable to drive thalamic spiking. This means that thalamic encoding is robust to sensory noise, however it induces a lag in sensory representation. Thus, the thalamus stabilizes encoding of sensory information, at the cost of response rate.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Publisher:	Frontiers
ISSN:	1662-5110
Funders:	Wellcome
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	22 December 2015
Last Modified:	04 May 2023 23:25
URI:	https://orca.cardiff.ac.uk/id/eprint/86326

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