Assessment of sleep in children with mucopolysaccharidosis Type III

Mahon, Louise Victoria, Lomax, Michelle, Grant, Sheena, Cross, Elaine, Hare, Dougal Julian, Wraith, James Ed, Jones, Simon, Bigger, Brian, Langford-Smith, Kia and Canal, Maria 2014. Assessment of sleep in children with mucopolysaccharidosis Type III. PLoS ONE 9 (2) , e84128. 10.1371/journal.pone.0084128

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Abstract

Sleep disturbances are prevalent in mucopolysaccharidosis Type III (MPS III), yet there is a lack of objective, ecologically valid evidence detailing sleep quantity, quality or circadian system. Eight children with MPS III and eight age-matched typically developing children wore an actigraph for 7–10 days/nights. Saliva samples were collected at three time-points on two separate days, to permit analysis of endogenous melatonin levels. Parents completed a sleep questionnaire and a daily sleep diary. Actigraphic data revealed that children with MPS III had significantly longer sleep onset latencies and greater daytime sleep compared to controls, but night-time sleep duration did not differ between groups. In the MPS III group, sleep efficiency declined, and sleep onset latency increased, with age. Questionnaire responses showed that MPS III patients had significantly more sleep difficulties in all domains compared to controls. Melatonin concentrations showed an alteration in the circadian system in MPS III, which suggests that treatment for sleep problems should attempt to synchronise the sleep-wake cycle to a more regular pattern. Actigraphy was tolerated by children and this monitoring device can be recommended as a measure of treatment success in research and clinical practice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Publisher:	Public Library of Science
ISSN:	1932-6203
Date of First Compliant Deposit:	4 September 2018
Date of Acceptance:	12 November 2013
Last Modified:	05 May 2023 21:26
URI:	https://orca.cardiff.ac.uk/id/eprint/86599

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