The S-cone PhNR and pattern ERG in primary open angle glaucoma

Drasdo, Neville, Aldebasi, Yousef Homoud F., Chiti, Zohreh, Mortlock, Katharine Eirlys ORCID: https://orcid.org/0000-0003-4745-7297, Morgan, James Edwards ORCID: https://orcid.org/0000-0002-8920-1065 and North, Rachel Valerie ORCID: https://orcid.org/0000-0002-6657-5099 2001. The S-cone PhNR and pattern ERG in primary open angle glaucoma. Investigative Ophthalmology and Visual Science 42 (6) , pp. 1266-1272.

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Abstract

PURPOSE. To compare the sensitivity of the photopic negative response (PhNR) from the shortwave (S)-sensitive and the long (L)- and medium (M)-wave–sensitive cone electroretinograms (ERGs), with the pattern electroretinogram (PERG) in the early stages of primary open-angle glaucoma (POAG). METHODS. Eighteen patients under treatment for diagnosed POAG and 19 normal control subjects were investigated. Scone ERGs were elicited using adaptation to 650-nm light to suppress L-cone activity, and substitution between 450 nm and 535 nm to silence M-cone response at luminances higher than rod saturation. PhNRs from the L&M-cone pathways were elicited by a 200-msec pulse of red light (650 nm) on a continuous blue (450 nm) background. PERGs were recorded in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standard. RESULTS. Each method showed a statistically significant difference in the two groups. The S-cone PhNR was the most sensitive test and provided the most statistically significant results, with the largest area enclosed by the receiver operating characteristic (ROC) curve. CONCLUSIONS. The findings indicate that all three types of ERG may be useful in glaucoma investigation. The L- and M-cone PhNRs may have a role in monitoring established glaucoma. The previously reported high sensitivity of the PERG was confirmed. Extensive diffuse damage to S-cone bipolar and bistratified ganglion cells appears to occur at a very early stage in POAG, owing to a pressure-related mechanism, and the S-cone PhNR was the most sensitive test. It may in future have an important role in diagnosis and monitoring of early glaucoma. Further investigation of this possibility is recommended

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Optometry and Vision Sciences Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RE Ophthalmology
Additional Information:	Confirmation received by publisher on 21 February 2014 that publisher's pdf can be self-archived 6 months after publication.
Publisher:	Association for Research in Vision and Ophthalmology
ISSN:	0146-0404
Date of First Compliant Deposit:	30 March 2016
Last Modified:	01 Nov 2023 07:57
URI:	https://orca.cardiff.ac.uk/id/eprint/867

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