Mass spectrometry uncovers molecular reactivities of coordination and organometallic gold (III) drug candidates in competitive experiments that correlate with their biological effects

Meier, Samuel M., Gerner, Christopher, Keppler, Bernhard K., Cinellu, Maria Agostina and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2016. Mass spectrometry uncovers molecular reactivities of coordination and organometallic gold (III) drug candidates in competitive experiments that correlate with their biological effects. Inorganic Chemistry 55 (9) , pp. 4248-4259. 10.1021/acs.inorgchem.5b03000

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Abstract

Mass spectrometry reveals profound differences in the reactivity of coordinative and organometallic gold(III) drug candidates to bionucleophiles, which impact their proposed modes of action targeting the selenoenzyme thioredoxin reductase. This provides a link between molecular reactivity and biological activity in vitro.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	American Chemical Society
ISSN:	0020-1669
Last Modified:	31 Oct 2022 11:00
URI:	https://orca.cardiff.ac.uk/id/eprint/87033

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