A process for analysis of microarray comparative genomics hybridisation studies for bacterial genomes

Carter, Ben Richard, Wu, Guanghui, Woodward, Martin J. and Anjum, Muna F. 2008. A process for analysis of microarray comparative genomics hybridisation studies for bacterial genomes. BMC Genomics 9 (1) , p. 53. 10.1186/1471-2164-9-53

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Abstract

Microarray based comparative genomic hybridisation (CGH) experiments have been used to study numerous biological problems including understanding genome plasticity in pathogenic bacteria. Typically such experiments produce large data sets that are difficult for biologists to handle. Although there are some programmes available for interpretation of bacterial transcriptomics data and CGH microarray data for looking at genetic stability in oncogenes, there are none specifically to understand the mosaic nature of bacterial genomes. Consequently a bottle neck still persists in accurate processing and mathematical analysis of these data. To address this shortfall we have produced a simple and robust CGH microarray data analysis process that may be automated in the future to understand bacterial genomic diversity.

Item Type:	Article
Status:	Published
Schools:	Medicine
Publisher:	BioMed Central
ISSN:	1471-2164
Funders:	SEEDCORN16
Last Modified:	10 Jun 2023 01:43
URI:	https://orca.cardiff.ac.uk/id/eprint/87844

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