Gavalda, Nuria, Gutierrez, Humberto  ORCID: https://orcid.org/0000-0002-5021-8636 and Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176
2009.
Developmental switch in NF-kappa B signalling required for neurite growth.
Development
136
(20)
, pp. 3405-3412.
10.1242/dev.035295
|
Abstract
For a given cell type, particular extracellular signals generate characteristic patterns of activity in intracellular signalling networks that lead to distinctive cell-type specific responses. Here, we report the first known occurrence of a developmental switch in the intracellular signalling network required for an identical cellular response to the same extracellular signal in the same cell type. We show that although NF-κB signalling is required for BDNF-promoted neurite growth from both foetal and postnatal mouse sensory neurons, there is a developmental switch between these stages in the NF-κB activation mechanism and the phosphorylation status of the p65 NF-κB subunit required for neurite growth. Shortly before birth, BDNF activates NF-κB by an atypical mechanism that involves tyrosine phosphorylation of IκBα by Src family kinases, and dephosphorylates p65 at serine 536. Immediately after birth, BDNF-independent constitutive activation of NF-κB signalling by serine phosphorylation of IκBα and constitutive dephosphorylation of p65 at serine 536 are required for BDNF-promoted neurite growth. This abrupt developmental switch in NF-κB signalling in a highly differentiated cell type illustrates an unsuspected plasticity in signalling networks in the generation of identical cellular responses to the same extracellular signal.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences |
| Subjects: | Q Science > QR Microbiology |
| Uncontrolled Keywords: | NF-κB; Neurite growth; Signalling; BDNF; Sensory neuron |
| Publisher: | The Company of Biologists Ltd |
| ISSN: | 0950-1991 |
| Funders: | Wellcome Trust |
| Last Modified: | 17 Oct 2022 10:38 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/8832 |
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