Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro

Ge, Z., Sanders, Andrew J. ORCID: https://orcid.org/0000-0002-7997-5286, Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409, Mansel, Robert E. ORCID: https://orcid.org/0000-0002-8051-0726 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2013. Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncology Reports 29 , pp. 1356-1364. 10.3892/or.2013.2259

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Abstract

Death receptor-3 (DR3) plays controversial roles in cancer. Currently, DR3 is known to be a functional receptor of vascular endothelial growth inhibitor (VEGI). The role of DR3 in breast cancer remains unclear. The present study investigated DR3 expression in a clinical cohort of breast cancer patients and its role in breast cancer cells in vitro. The expression of DR3 was examined in a breast cancer cohort using quantitative PCR (Q-PCR) and immunohistochemistry (IHC) in comparison to the patients' data. In vitro function of DR3 was examined through the targeting of this molecule in MCF7 and MDA-MB-231 breast cancer cells using ribozyme transgene technology. Decreased DR3 expression was noted in breast cancer tissues compared to normal tissues and decreased expression of DR3 was generally associated with a poorer prognosis as well as a significantly shorter long-term survival (p=0.038). Targeting of DR3 in vitro in breast cancer cell lines resulted in impaired migratory rates compared to respective control cells. Collectively, these data suggest a complex role for DR3 in breast cancer development and progression.

Item Type:	Article
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Spandidos Publications
Last Modified:	01 Nov 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/88369

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