Dental pulp stem cells and their potential roles in central nervous system regeneration and repair

Young, Fraser ORCID: https://orcid.org/0000-0003-0779-3835, Sloan, Alastair James ORCID: https://orcid.org/0000-0002-1791-0903 and Song, Bing ORCID: https://orcid.org/0000-0001-9356-2333 2013. Dental pulp stem cells and their potential roles in central nervous system regeneration and repair. Journal of Neuroscience Research 91 (11) , pp. 1383-1393. 10.1002/jnr.23250

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Abstract

Functional recovery from injuries to the brain or spinal cord represents a major clinical challenge. The transplantation of stem cells, traditionally isolated from embryonic tissue, may help to reduce damage following such events and promote regeneration and repair through both direct cell replacement and neurotrophic mechanisms. However, the therapeutic potential of using embryonic stem/progenitor cells is significantly restricted by the availability of embryonic tissues and associated ethical issues. Populations of stem cells reside within the dental pulp, representing an alternative source of cells that can be isolated with minimal invasiveness, and thus should illicit fewer moral objections, as a replacement for embryonic/fetal-derived stem cells. Here we discuss the similarities between dental pulp stem cells (DPSCs) and the endogenous stem cells of the central nervous system (CNS) and their ability to differentiate into neuronal cell types. We also consider in vitro and in vivo studies demonstrating the ability of DPSCs to help protect against and repair neuronal damage, suggesting that dental pulp may provide a viable alternative source of stem cells for replacement therapy following CNS damage.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Subjects:	R Medicine > RK Dentistry
Uncontrolled Keywords:	dental pulp stem cells; spinal cord injury; stroke; neuroprotection
Publisher:	Wiley
ISSN:	0360-4012
Last Modified:	01 Nov 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/88466

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