Thomas, Rhys Huw  ORCID: https://orcid.org/0000-0003-2062-8623, Walsh, Jordana, Church, Carla, Sills, Graeme J., Marson, Anthony G., Baker, Gus A. and Rees, Mark I.
2014.
A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy.
Epilepsy & Behavior
36
, pp. 124-129.
10.1016/j.yebeh.2014.04.027
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Abstract
The study of juvenile myoclonic epilepsy is important in that: it is common and heterogeneous; the etiology is unknown; and patients report broad cognitive problems. We utilized a broad battery of neuropsychometric tests to assess the following: intellectual function, memory, language and naming, executive function, the impact of epilepsy, and antiepilepsy drug side effects. Sixty people with drug-refractory JME were interviewed, and performance was profoundly impaired across the range of tests. Impairments included the following: full-scale IQ (89, p < 0.001); processing speed (86, p < 0.001); visual memory (immediate and delayed) more affected than verbal memory; verbal fluency and inhibition (p < 0.001); and self-reported drug side effects (p < 0.001). Eighty-three percent of patients exhibited frank executive dysfunction, which was moderate to severe in 66%. Regression modeling confirmed that an early age at onset and the need for polytherapy were associated with poorer cognitive outcomes. This study confirms previous reports of executive dysfunction in a larger cohort and with greater statistical rigor. We also identified a high prevalence of neurotoxicity symptoms such as fatigue and poorer functioning across intellectual and memory tests than had previously been reported.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Uncontrolled Keywords: | Juvenile myoclonic epilepsy; Psychology; Executive function; Memory; Cognition |
| Publisher: | Elsevier |
| ISSN: | 1525-5050 |
| Date of Acceptance: | 30 April 2014 |
| Last Modified: | 01 Nov 2022 09:38 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/88692 |
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