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A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy

Thomas, Rhys Huw, Walsh, Jordana, Church, Carla, Sills, Graeme J., Marson, Anthony G., Baker, Gus A. and Rees, Mark I. 2014. A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy. Epilepsy & Behavior 36 , pp. 124-129. 10.1016/j.yebeh.2014.04.027

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The study of juvenile myoclonic epilepsy is important in that: it is common and heterogeneous; the etiology is unknown; and patients report broad cognitive problems. We utilized a broad battery of neuropsychometric tests to assess the following: intellectual function, memory, language and naming, executive function, the impact of epilepsy, and antiepilepsy drug side effects. Sixty people with drug-refractory JME were interviewed, and performance was profoundly impaired across the range of tests. Impairments included the following: full-scale IQ (89, p < 0.001); processing speed (86, p < 0.001); visual memory (immediate and delayed) more affected than verbal memory; verbal fluency and inhibition (p < 0.001); and self-reported drug side effects (p < 0.001). Eighty-three percent of patients exhibited frank executive dysfunction, which was moderate to severe in 66%. Regression modeling confirmed that an early age at onset and the need for polytherapy were associated with poorer cognitive outcomes. This study confirms previous reports of executive dysfunction in a larger cohort and with greater statistical rigor. We also identified a high prevalence of neurotoxicity symptoms such as fatigue and poorer functioning across intellectual and memory tests than had previously been reported.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Juvenile myoclonic epilepsy; Psychology; Executive function; Memory; Cognition
Publisher: Elsevier
ISSN: 1525-5050
Date of Acceptance: 30 April 2014
Last Modified: 03 Jun 2019 13:13

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