The pupillary and ciliary components of the cat Edinger-Westphal nucleus: a transsynaptic transport investigation

Erichsen, Jonathan Thor ORCID: https://orcid.org/0000-0003-1545-9853 and May, Paul J. 2002. The pupillary and ciliary components of the cat Edinger-Westphal nucleus: a transsynaptic transport investigation. Visual Neuroscience 19 (1) , pp. 15-29. 10.1017/S0952523801191029

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Abstract

The distribution of preganglionic motoneurons supplying the ciliary ganglion in the cat was defined both qualitatively and quantitatively. These cells were retrogradely labeled directly, following injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) into the ciliary ganglion, or were transsynaptically labeled following injections of WGA into the vitreous chamber. Almost half of the cells are distributed rostral to the oculomotor nucleus, both in and lateral to the anteromedian nucleus. Of the remaining preganglionic motoneurons, roughly 20% of the total are located dorsal to the oculomotor nucleus. Strikingly few of these neurons are actually found within the Edinger-Westphal nucleus proper. Instead, the majority are found in the adjacent supraoculomotor area or along the midline between the two somatic nuclei. An additional population, roughly 30% of the total, is located ventral to the oculomotor nucleus. This study also provides evidence for a functional subdivision of this preganglionic population. Pupil-related preganglionic motoneurons were transsynaptically labeled by injecting WGA into the anterior chamber, while lens-related preganglionic motoneurons were transsynaptically labeled by injecting WGA into the ciliary muscle. The results suggest that the pupil-related preganglionic motoneurons, that is, those controlling the iris sphincter pupillae muscle, are located rostrally, in and lateral to the anteromedian nucleus. In contrast, lens-related preganglionic motoneurons, that is, those controlling the ciliary muscle are particularly prevalent caudally, both dorsal and ventral to the oculomotor nucleus. Thus, the cat intraocular muscle preganglionic innervation is spatially organized with respect to function, despite the dispersed nature of its distribution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Uncontrolled Keywords:	Oculomotor; Lens; Iris; Parasympathetic; Accommodation; Near response
Additional Information:	Publisher’s copyright requirements: “All contributors retain the right to post the definitive version of the contribution as published at Cambridge Journals Online (in PDF or HTML form) in the Institutional Repository of the institution in which they worked at the time the paper was first submitted, or (for appropriate journals) in PubMed Central or UK PubMed Central, no sooner than one year after first publication of the paper in the journal, subject to file availability and provided the posting includes a prominent statement of the full bibliographical details, a copyright notice in the name of the copyright holder (Cambridge University Press or the sponsoring Society, as appropriate), and a link to the online edition of the journal at Cambridge Journals Online. Inclusion of this definitive version after one year in Institutional Repositories outside of the institution in which the contributor worked at the time the paper was first submitted will be subject to the additional permission of Cambridge University Press (not to be unreasonably withheld). See: http://journals.cambridge.org/action/forAuthors?page=copyright
Publisher:	Cambridge University Press
ISSN:	1469-8714
Last Modified:	13 May 2023 03:40
URI:	https://orca.cardiff.ac.uk/id/eprint/887

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