Reduced RanBPM expression is associated with distant metastasis in gastric cancer and chemoresistance

Shao, Shuai, Sun, Ping-Hui, Satherley, Lucy, Gao, Xiangyu, Ji, Ke, Feng, Yi ORCID: https://orcid.org/0000-0002-2445-1290, Jia, Yongning, Ji, Jiafu, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2016. Reduced RanBPM expression is associated with distant metastasis in gastric cancer and chemoresistance. Anticancer Research 36 (3) , pp. 1295-1304.

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Abstract

Aim: Ran binding protein M (RanBPM) is a ubiquitous, nucleocytoplasmic protein that serves as a scaffolding molecule. This study aimed to investigate the role of RanBPM in gastric cancer. Materials and Methods: RanBPM expression in human gastric cancer tissue samples was analyzed using real-time polymerase chain reaction. The effect of RanBPM on cellular functions was examined in RanBPM-knockdown gastric cells and with in vitro cell functional assays. Results: Gastric tumors with distant metastases expressed lower levels of RanBPM transcripts compared to tumours without detectable metastases (p=0.036). RanBPM knockdown in gastric cancer cells reduced adhesion and promoted survival of gastric cancer cells after exposure to methotrexate and fluorouracil. Conclusion: RanBPM levels were reduced in gastric tumors with distant metastases. This suggests that loss of RanBPM expression may play an important role in gastric cancer tumor development and metastasis. Reduced RanBPM expression is also associated with chemoresistance of gastric cancer cells.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	International Institute of Anticancer Research
ISSN:	0250-7005
Funders:	Cardiff China Medical Scholarship and Cancer Research Wales
Date of First Compliant Deposit:	11 April 2016
Date of Acceptance:	14 February 2016
Last Modified:	01 Nov 2022 09:44
URI:	https://orca.cardiff.ac.uk/id/eprint/89060

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