Prostate Apoptosis Response-4 (PAR4) suppresses growth and invasion of breast cancer cells and is positively associated with patient survival

Satherley, Lucy, Sun, P. H., Ke, Ji, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869, Hargest, Rachel ORCID: https://orcid.org/0000-0001-9830-3832, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2016. Prostate Apoptosis Response-4 (PAR4) suppresses growth and invasion of breast cancer cells and is positively associated with patient survival. Anticancer Research 36 (3) , pp. 1227-1236.

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Abstract

BACKGROUND: Prostate apoptosis response-4 (PAR4) plays an important role in apoptosis and survival of cancer cells. The current study aimed to further elucidate its role in breast cancer. MATERIALS AND METHODS: PAR4 expression in human breast cancer tissue was examined using quantitative polymerase chain reaction (qPCR) and immunohistochemical staining (IHC). Plasmids containing full-length human PAR4 coding sequence were used to overexpress PAR4 in breast cancer cells and the effect on cellular functions was examined using both in vitro functional assays and an in vivo murine model. RESULTS: Patients with low PAR4 transcript levels had poorer overall survival. PAR4 expression may be associated with differential expression of oestrogen receptors α and β in the tumours. Overexpression of PAR4 in MDA-MB-231 cells resulted in reduced cell growth and invasion, and also reduced in vivo tumour growth. CONCLUSION: Decreased PAR4 expression in breast cancer is associated with shorter survival. PAR4 suppresses growth and invasiveness of breast cancer cells.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	International Institute of Anticancer Research
Funders:	Royal College of Surgeons and Cancer Research Wales
Date of First Compliant Deposit:	11 April 2016
Date of Acceptance:	14 February 2016
Last Modified:	01 Nov 2022 09:44
URI:	https://orca.cardiff.ac.uk/id/eprint/89062

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