Haptoglobin duplicon, hemoglobin, and vitamin C: analyses in the British Women's Heart and Health Study and Caerphilly Prospective Study

Guthrie, Philip A. I., Abdollahi, Mohammad R., Gaunt, Tom, Lawlor, Debbie A., Ben-Shlomo, Yoav, Gallacher, John Edward ORCID: https://orcid.org/0000-0002-2394-5299, Davey Smith, George, Day, Ian N. M. and Rodriguez, Santiago 2014. Haptoglobin duplicon, hemoglobin, and vitamin C: analyses in the British Women's Heart and Health Study and Caerphilly Prospective Study. Disease Markers 2014 , 529456. 10.1155/2014/529456

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Abstract

Background. Haptoglobin acts as an antioxidant by limiting peroxidative tissue damage by free hemoglobin. The haptoglobin gene allele Hp2 comprises a 1.7 kb partial duplication. Relative to allele Hp1, Hp2 carriers form protein multimers, suboptimal for hemoglobin scavenging. Objective. To examine the association of haptoglobin genotype with a range of phenotypes, with emphasis on vitamin C and hemoglobin levels. Methods. We applied a quantitative PCR assay for the duplication junction to two population cohorts including 2747 British women and 1198 British men. We examined the association of haptoglobin duplicon copy number with hemoglobin and vitamin C and used the copy number to complete a phenome scan. Results. Hemoglobin concentrations were greater in those with Hp2,2 genotype, in women only (Hp1,1 13.45 g/dL, Hp1,2 13.49 g/dL, Hp2,2 13.61 g/dL; ), though statistically there was no evidence of a difference between the sexes ( value = 1.2, ). Haptoglobin genotype was not associated with vitamin C or any other phenotype in either cohort. Conclusions. Our results do not support association of haptoglobin genotype with vitamin C or with other phenotypes measured in two population cohorts. The apparent association between haptoglobin genotype and hemoglobin in the women’s cohort merits further investigation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Copyright © 2014 Philip A. I. Guthrie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher:	Hindawi Publishing
ISSN:	0278-0240
Date of First Compliant Deposit:	15 April 2016
Date of Acceptance:	7 November 2014
Last Modified:	04 May 2023 19:22
URI:	https://orca.cardiff.ac.uk/id/eprint/89169

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