Willis, Mark, Harding, Katharine, Wardle, Mark, Pickersgill, Trevor, Tomassini, Valentina  ORCID: https://orcid.org/0000-0002-7368-6280 and Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909
2014.
Alemtuzumab: Long term follow-up in a single centre cohort.
Journal of Neurology, Neurosurgery & Psychiatry
85
(10)
, A1-A57.
10.1136/jnnp-2014-309236.8
|
Abstract
Introduction Alemtuzumab is an anti-CD52 monoclonal antibody, approved for the treatment of relapsing multiple sclerosis (RMS). However, it has significant side effects and long-term follow-up is required to provide accurate information for patient management and counselling. Methods Patients were followed prospectively within an active surveillance program and standardised data collected on a regional database. Data on patient demographics, adverse events, disability trajectories (EDSS), relapses and retreatment intervals were analysed. Results 96 patients with highly active RMS were identified (69F:27M). Mean follow-up post treatment was 5.1 years. Most patients received 2 annual cycles but 27 (28.1%) received 3, 7(7.3%) received 4 and 2 (2.1%) received 5. Pre-and post-treatment annualised relapse rates were 2.1 and 0.4 respectively. Mean change in EDSS from baseline was 0.44. 8 patients developed secondary progression a mean of 2.8 years post treatment. A range of autoimmune disorders (AID), notably thyroid disease was identified in 45 (47%). Discussion Our data supports the effectiveness of alemtuzumab in patients with RMS in reducing relapse rates. However, despite a paucity of inflammatory disease activity, disability accumulation continued in some patients. Overall retreatment rate was 37.5% and AID, whilst common, could be effectively identified through routine surveillance processes and managed without serious consequence.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Publisher: | BMJ Publishing Group |
| ISSN: | 0022-3050 |
| Last Modified: | 11 Jul 2025 21:24 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/89241 |
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