The impact of TIMM17A on aggressiveness of human breast cancer cells

Yang, Xiaomei, Si, Yang, Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2016. The impact of TIMM17A on aggressiveness of human breast cancer cells. Anticancer Research 36 (3) , pp. 1237-1241.

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Abstract

Background: The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. Materials and Methods: Anti-TIMM17A transgenes were stably transfected into MDA MB-231 and MCF-7 breast cancer cell lines. The impact of TIMM17A knock-down on cell migration and invasion were evaluated using the respective cell models. Results: Reducing the expression of TIMM17A in breast cancer cells resulted in reduction of cell migration using electric cell-substrate impedance sensing. It was also found that reduction of TIMM17A expression resulted in reduction of cell invasion compared to vector control. Conclusion: TIMM17A has a profound impact on the cellular function of breast cancer cells. A decrease of TIMM17A expression is associated with the reduction of the aggressiveness of breast cancer cells. TIMM17A, therefore, has potential in prognosis and treatment of breast cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	International Institute of Anticancer Research
ISSN:	0250-7005
Date of Acceptance:	23 February 2016
Last Modified:	01 Nov 2022 10:08
URI:	https://orca.cardiff.ac.uk/id/eprint/90383

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