Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

De Almeida, A. ORCID: https://orcid.org/0000-0002-6889-1503, Martins, A. P., Mósca, A. F., Wijma, H. J., Prista, C., Soveral, G. and Casini, A. ORCID: https://orcid.org/0000-0003-1599-9542 2016. Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors? Molecular BioSystems 12 , pp. 1564-1573. 10.1039/C6MB00013D

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Abstract

The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC). For comparison, the effects of pH on the gating of rat AQP3 have also been characterized in yeast. The obtained results highlight similarities as well as differences between the two isoforms. In addition, we investigated the molecular mechanism of hAQP3 pH gating in silico, which may disclose new pathways to AQP regulation by small molecule inhibitors, and therefore may be important for drug development.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1742-206X
Date of Acceptance:	2 March 2016
Last Modified:	01 Nov 2022 10:21
URI:	https://orca.cardiff.ac.uk/id/eprint/91142

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