Direct ex vivo measurement of CD8+ T-Lymphocyte responses to human parvovirus B19

Tolfvenstam, T., Oxenius, A., Price, D. A., Shacklett, B. L., Spiegel, H. M. L., Hedman, K., Norbeck, O., Levi, M., Olsen, K., Kantzanou, M., Nixon, D. F., Broliden, K. and Klenerman, P. 2001. Direct ex vivo measurement of CD8+ T-Lymphocyte responses to human parvovirus B19. Journal of Virology 75 (1) , pp. 540-543. 10.1128/JVI.75.1.540-543.2001

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Abstract

Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.

Item Type:	Article
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology > QR355 Virology
Publisher:	American Society for Microbiology
ISSN:	0022-538X
Date of First Compliant Deposit:	1 June 2016
Date of Acceptance:	28 September 2000
Last Modified:	02 Jun 2016 12:21
URI:	https://orca.cardiff.ac.uk/id/eprint/91446

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