Ghafoor, Abdul, Aslam, Noreen, Elliott, Mark Christopher ORCID: https://orcid.org/0000-0003-0132-0818, Sajid, Naveed, Nasrullah, Muhammad, Ashraf, Muhammad, Ain, Qurat-ul- and Khan, Misbahul Ain 2016. Synthesis, characterization and biological evaluation of some new oxino bis-pyrazole derivatives. Asian Journal of Chemistry 28 (8) , pp. 1648-1652. 10.14233/ajchem.2016.19736 |
PDF
- Published Version
Available under License Creative Commons Attribution. Download (535kB) |
Official URL: http://dx.doi.org/10.14233/ajchem.2016.19736
Abstract
Novel oxino bis-pyrazoles were obtained by two step reactions of 3-methyl-1-phenyl pyrazoline-5-one, cyanoacetamide and aryl- or alkylaldehydes, in the presence of catalytic amounts of triethylamine and ethanol as a solvent. All the synthesized compounds were evaluated for their inhibitory activities against butyrylcholinesterase (BChE) and bovine a-chymotrypsin. Two compounds, 8 and 9 were found to be good inhibitors of enzyme BChE with IC50 values of 52.74 ± 0.006 and 51.85 ± 0.005 μM, respectively.
Item Type: | Article |
---|---|
Date Type: | Published Online |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | Asian Journal of Chemistry |
ISSN: | 0970-7077 |
Date of First Compliant Deposit: | 16 June 2016 |
Date of Acceptance: | 24 March 2016 |
Last Modified: | 02 May 2023 18:28 |
URI: | https://orca.cardiff.ac.uk/id/eprint/91905 |
Citation Data
Cited 2 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |