Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke

Leung, Ling Yan, Chan, Cangel Pui Yee, Leung, Yuk Ki, Jiang, Hui Lin, Abrigo, Jill Morales, Wang, De Feng, Chung, Joseph Shun Hang, Rainer, Timothy ORCID: https://orcid.org/0000-0003-3355-3237 and Graham, Colin Alexander 2014. Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke. Clinica Chimica Acta 433 , pp. 139-144. 10.1016/j.cca.2014.03.007

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Abstract

Background The present study aimed to investigate and compare plasma concentrations of miR-124-3p and miR-16 as diagnostic markers in acute stroke. Methods miR-124-3p and miR-16 concentrations in 93 stroke patients were analyzed using real-time polymerase chain reaction. The primary outcome was the differentiation of hemorrhagic and ischemic stroke. Results Of 93 patients, 74 (79.6%) were diagnosed as ischemic stroke (IS) and 19 (20.4%) were diagnosed as hemorrhagic stroke (HS). Median plasma 124-3p concentrations taken within 24 h of symptom onset were higher in HS patients than that in IS patients (3.8 × 105 vs 2.0 × 105 copies/ml plasma, p = 0.0109), while median miR-16 concentration in IS patients were higher than that in HS patients (1.6 × 109 vs 1.3 × 109 copies/ml plasma, p = 0.0399). The odds ratio (OR) for discriminating HS and IS with miR-124-3p and miR-16 was 5.37 and 9.75 respectively. Conclusion Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0009-8981
Date of Acceptance:	4 March 2014
Last Modified:	01 Nov 2022 10:42
URI:	https://orca.cardiff.ac.uk/id/eprint/92630

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