Leung, Ling Yan, Chan, Cangel Pui Yee, Leung, Yuk Ki, Jiang, Hui Lin, Abrigo, Jill Morales, Wang, De Feng, Chung, Joseph Shun Hang, Rainer, Timothy  ORCID: https://orcid.org/0000-0003-3355-3237 and Graham, Colin Alexander
2014.
Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke.
Clinica Chimica Acta
433
, pp. 139-144.
10.1016/j.cca.2014.03.007
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Abstract
Background The present study aimed to investigate and compare plasma concentrations of miR-124-3p and miR-16 as diagnostic markers in acute stroke. Methods miR-124-3p and miR-16 concentrations in 93 stroke patients were analyzed using real-time polymerase chain reaction. The primary outcome was the differentiation of hemorrhagic and ischemic stroke. Results Of 93 patients, 74 (79.6%) were diagnosed as ischemic stroke (IS) and 19 (20.4%) were diagnosed as hemorrhagic stroke (HS). Median plasma 124-3p concentrations taken within 24 h of symptom onset were higher in HS patients than that in IS patients (3.8 × 105 vs 2.0 × 105 copies/ml plasma, p = 0.0109), while median miR-16 concentration in IS patients were higher than that in HS patients (1.6 × 109 vs 1.3 × 109 copies/ml plasma, p = 0.0399). The odds ratio (OR) for discriminating HS and IS with miR-124-3p and miR-16 was 5.37 and 9.75 respectively. Conclusion Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Elsevier |
| ISSN: | 0009-8981 |
| Date of Acceptance: | 4 March 2014 |
| Last Modified: | 01 Nov 2022 10:42 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/92630 |
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