Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk

Baum, Larry, Ng, Ho Keung, Woo, Kam Sang, Tomlinson, Brian, Rainer, Timothy Hudson ORCID: https://orcid.org/0000-0003-3355-3237, Chen, Xiangyan, Cheung, Wing Sze, Yin Chan, Daniel Kam, Thomas, G. Neil, Wai Tong, Cindy See and Wong, Ka Sing 2006. Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk. Clinical Biochemistry 39 (3) , pp. 191-195. 10.1016/j.clinbiochem.2006.01.010

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Abstract

Objectives: Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease. Design and methods: In a case control study, we genotyped 242 ischemic stroke, 231 myocardial infarction (MI), and 310 healthy control subjects, all Chinese. Results: R-containing genotypes (R+) were associated with vascular disease, OR = 1.5, P = 0.03. RR was increased in MI patients who were either smokers (OR = 3.1, P = 0.01), male, or younger than 60. R+ but not RR genotypes were increased in stroke patients, particularly large artery type (OR = 2.6 and P = 0.02 for R+, OR = 1.0 for RR) or among smokers. The relative dearth of RR in stroke might be due to earlier MI or death in at-risk people, such as smokers. R+ genotypes were increased with stroke in hypertensive (OR = 2.1, P = 0.02) but not normotensive (OR = 1.0) subjects. Conclusions: PON1 192R+ genotypes were associated with stroke and MI, particularly in subsets of patients, in patterns suggesting a possible survivor effect.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Paraoxonase; Polymorphism; Ischemic stroke; Myocardial infarction
Publisher:	Elsevier
ISSN:	0009-9120
Date of Acceptance:	2 January 2006
Last Modified:	01 Nov 2022 10:47
URI:	https://orca.cardiff.ac.uk/id/eprint/92863

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