Early role of neutrophil l-selectin in posttraumatic acute lung injury

Rainer, Timothy ORCID: https://orcid.org/0000-0003-3355-3237, Lam, Nicole Y. L., Chan, Tina Y. F. and Cocks, Robert A. 2000. Early role of neutrophil l-selectin in posttraumatic acute lung injury. Critical Care Medicine 28 (8) , pp. 2766-2772. 10.1097/00003246-200008000-00014

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Abstract

Objective: To investigate whether early numerical and functional changes in circulating neutrophils and expression of neutrophil l-selectin and soluble l-selectin are related to the subsequent development of posttraumatic acute lung injury (ALI), the systemic inflammatory response syndrome, sepsis, and organ failure. Design: Prospective study of whole blood and plasma samples to assess numerical and functional changes in circulating neutrophils and in soluble l-selectin. Setting: The emergency department of a university hospital. Patients: A total of 147 patients admitted to the resuscitation room after trauma were compared with 69 control subjects. Ten patients developed ALI. Laboratory Analysis: Flow cytometry of whole blood and ELISA of plasma. Results: Total leukocyte and neutrophil counts, expression of L-selectin, and the ratio of neutrophil to plasma L-selectin increased with injury and were highest in those who developed ALI. Soluble L-selectin decreased with injury severity and was lowest in those who developed ALI. Conclusions: Early changes in the average expression of L-selectin per cell do not correlate with the development of subsequent posttraumatic ALI. However, the development of ALI is related to the total expression of L-selectin in the neutrophil mass, and the most striking association is in those with lower concentrations of plasma L-selectin.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Lippincott Williams & Wilkins
ISSN:	0090-3493
Last Modified:	01 Nov 2022 10:49
URI:	https://orca.cardiff.ac.uk/id/eprint/92933

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