Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

Xie, Meng, Dart, Dafydd Alwyn, Owen, Sioned, Wen, Xianzi, Ji, Jiafu and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2016. Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review). Oncology Reports 36 (3) , pp. 1191-1198. 10.3892/or.2016.4908

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Abstract

Gastric cancer (GC) remains the third most common cause of cancer deaths worldwide and carries a high rate of metastatic risk contributing to the main cause of treatment failure. An accumulation of data has resulted in a better understanding of the molecular network of GC, however, gaps still exist between the unique bio-resources and clinical application. MicroRNAs are an important part of non-coding RNAs and behave as major regulators of tumour biology, alongside their well-known roles as intrinsic factors of gene expression in cellular processes, via their post-transcriptional regulation of components of signalling pathways in a coordinated manner. Deregulation of the miR-1, -133 and -206 family plays a key role in tumorigenesis, progression, invasion and metastasis. This review aims to provide a summary of recent findings on the miR-1, -133 and -206 family in GC and how this knowledge might be exploited for the development of future miRNA-based therapies for the treatment of GC.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Spandidos Publications
ISSN:	1021-335X
Last Modified:	06 Jul 2023 01:38
URI:	https://orca.cardiff.ac.uk/id/eprint/93360

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