Using High-Field Magnetic Resonance Imaging to Estimate Distensibility of the Middle Cerebral Artery

Warnert, Esther A.H, Verbree, Jasper, Wise, Richard ORCID: https://orcid.org/0000-0003-1700-2144 and van Osch, Matthias J.P. 2016. Using High-Field Magnetic Resonance Imaging to Estimate Distensibility of the Middle Cerebral Artery. Neurodegenerative Diseases 16 (5-6) , pp. 407-410. 10.1159/000446397

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Abstract

Although cerebral arterial stiffness may be an important marker for cerebrovascular health, there is not yet a measurement that accurately reflects the distensibility of major intracranial arteries. Herein, we aim to noninvasively measure distension of the human middle cerebral artery (MCA). Methods: Ten healthy volunteers (age: 30.3 ± 10.8 years) underwent ultra-high-field (7-tesla) MRI scanning. Time-of-flight angiography and phase-contrast flow imaging were used to locate the M1 segment of the MCA and to determine the occurrence of systole and diastole. High-resolution cross-sectional cardiac triggered T2-weighted images of the M1 segment of the MCA were acquired in systole and diastole. Results: The average distension of the MCA area from diastole to systole was 2.58% (range: 0.08%-6.48%). There was no significant correlation between MCA distension and the pulsatility index, calculated from the phase-contrast flow velocity profiles. Conclusion: These results lead to the first noninvasive image-based estimation of distensibility of the MCA (approx. 5.8 × 10-4 mm Hg-1) and demonstrate that ultra-high-field MRI could be a promising tool for investigating distensibility of intracranial arteries in relation to cerebrovascular pathology.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology
Publisher:	Karger
ISSN:	16602854
Funders:	Wellcome Trust
Date of First Compliant Deposit:	27 July 2016
Date of Acceptance:	25 April 2016
Last Modified:	05 May 2023 06:43
URI:	https://orca.cardiff.ac.uk/id/eprint/93369

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