Kaiser, Felix, Schmidt, Andrea, Heydenreuter, Wolfgang, Altmann, Philipp Johannes, Casini, Angela  ORCID: https://orcid.org/0000-0003-1599-9542, Sieber, Stephan A. and Kühn, Fritz Elmar
2016.
Self-assembled palladium and platinum coordination cages: Photophysical studies and anticancer activity.
European Journal of Inorganic Chemistry
2016
(33)
, pp. 5189-5196.
10.1002/ejic.201600811
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Abstract
Self-assembled coordination cages are interesting as drug delivery systems. Therefore, the synthesis of new ML (M = Pd, Pt) molecular cages, derived from highly fluorescent, rigid polyaromatic ligands is reported and the first PtL cage with a ligand consisting of three pyridine moieties is described. Photophysical properties were examined showing high quantum yieldsof up to 48% for the methoxy-functionalized ligands. Coordination of the ligands to palladium and platinum ions reduces the metallocages' fluorescence, however. The host-guest chemistry of the palladium cage with cisplatin is investigated confirming the encapsulation. The cages encapsulating cisplatin show a significantly increased cytotoxicity towards A549 (human lung adenocarcinoma) cells compared to cisplatin, and thus appear to be promising delivery vectors for the anticancer drug cisplatin.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Subjects: | Q Science > QD Chemistry |
| Publisher: | Wiley |
| ISSN: | 1434-1948 |
| Date of First Compliant Deposit: | 5 September 2016 |
| Date of Acceptance: | 23 August 2016 |
| Last Modified: | 27 Nov 2024 04:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/94190 |
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