The chick as an animal model of eye disease

Hocking, Paul M. and Guggenheim, Jeremy Andrew ORCID: https://orcid.org/0000-0001-5164-340X 2013. The chick as an animal model of eye disease. Drug Discovery Today: Disease Models 10 (4) , e225-e230. 10.1016/j.ddmod.2014.02.003

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Abstract

A diverse range of chicken lines harbouring highly-penetrant, spontaneously-occurring mutations with an ocular phenotype have been identified over the past 40 years. These lines serve as models for human monogenic disorders including ocular albinism, retinal dystrophies such as Leber's congenital amaurosis, and coloboma, as well as the common complex traits glaucoma and myopia. Recent technical advances in gene targeting, mapping quantitative trait loci, and phenotypic characterisation of eye phenotypes offer exciting prospects for exploiting chicken genomic resources in fundamental and translational eye research.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Publisher:	Elsevier
ISSN:	1740-6757
Date of First Compliant Deposit:	15 September 2016
Last Modified:	01 Dec 2024 07:30
URI:	https://orca.cardiff.ac.uk/id/eprint/94590

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