Synthesis of tertiary enamides by Ag2CO3-promoted Pd-catalyzed alkenylation of acyclic secondary amides

Delforge, Arnaud, Georgiou, Irene, Kremer, Adrian, Wouters, Johan and Bonifazi, Davide ORCID: https://orcid.org/0000-0001-5717-0121 2016. Synthesis of tertiary enamides by Ag2CO3-promoted Pd-catalyzed alkenylation of acyclic secondary amides. Organic Letters 18 (19) , pp. 4844-4847. 10.1021/acs.orglett.6b02305

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Abstract

A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Chemistry
Publisher:	American Chemical Society
ISSN:	1523-7060
Date of First Compliant Deposit:	3 October 2016
Date of Acceptance:	20 September 2016
Last Modified:	12 Nov 2024 17:15
URI:	https://orca.cardiff.ac.uk/id/eprint/95046

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