Rienecker, Kira, Hill, Matthew  ORCID: https://orcid.org/0000-0001-6776-8709 and Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712
2016.
Methods of epigenome editing for probing the function of genomic imprinting.
Epigenomics
8
(10)
, pp. 1389-1398.
10.2217/epi-2016-0073
|
Preview |
PDF
- Accepted Post-Print Version
Download (732kB) | Preview |
Abstract
The curious patterns of imprinted gene expression draw interest from several scientific disciplines to the functional consequences of genomic imprinting. Methods of probing the function of imprinting itself have largely been indirect and correlational, relying heavily on conventional transgenics. Recently, the burgeoning field of epigenome editing has provided new tools and suggested strategies for asking causal questions with site specificity. This perspective article aims to outline how these new methods may be applied to questions of functional imprinting and, with this aim in mind, to suggest new dimensions for the expansion of these epigenome-editing tools.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Publisher: | Future Medicine |
| ISSN: | 1750-1911 |
| Date of First Compliant Deposit: | 24 October 2016 |
| Date of Acceptance: | 5 August 2016 |
| Last Modified: | 24 Nov 2024 04:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/95316 |
Citation Data
Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |
Dimensions
Dimensions