Hippocampal activity patterns carry information about objects in temporal context

Hsieh, Liang-Tien, Gruber, Matthias J. ORCID: https://orcid.org/0000-0002-2754-0520, Jenkins, Lucas J. and Ranganath, Charan 2014. Hippocampal activity patterns carry information about objects in temporal context. Neuron 81 (5) , pp. 1165-1178. 10.1016/j.neuron.2014.01.015

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Abstract

The hippocampus is critical for human episodic memory, but its role remains controversial. One fundamental question concerns whether the hippocampus represents specific objects or assigns context-dependent representations to objects. Here, we used multivoxel pattern similarity analysis of fMRI data during retrieval of learned object sequences to systematically investigate hippocampal coding of object and temporal context information. Hippocampal activity patterns carried information about the temporal positions of objects in learned sequences, but not about objects or temporal positions in random sequences. Hippocampal activity patterns differentiated between overlapping object sequences and between temporally adjacent objects that belonged to distinct sequence contexts. Parahippocampal and perirhinal cortex showed different pattern information profiles consistent with coding of temporal position and object information, respectively. These findings are consistent with models proposing that the hippocampus represents objects within specific temporal contexts, a capability that might explain its critical role in episodic memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Publisher:	Elsevier (Cell Press)
ISSN:	0896-6273
Date of First Compliant Deposit:	22 November 2017
Date of Acceptance:	31 December 2013
Last Modified:	15 Nov 2023 01:47
URI:	https://orca.cardiff.ac.uk/id/eprint/96034

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