Intra-articular injections for osteoarthritis: from bench to bedside, can we teach old drugs new tricks?

Lee, Paul Yuh Fang and Brock, James 2016. Intra-articular injections for osteoarthritis: from bench to bedside, can we teach old drugs new tricks? Journal of Arthritis 5 (3) , 1000e111. 10.4172/2167-7921.1000e111

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Abstract

The two articles in this month’s press of e Journal of Arthritis, one by Ekinci et al. titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al. titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]. Firstly that there is a paucity of high quality literature in the eld that o en leads to inconclusive or misrepresented conclusions on drug e cacy in established treatments [1,2]. e articles also highlight the heterogeneity in injection procedure, site, concentration, preparation and outcome measurements [1,2]. is editorial will, therefore, provide a concise review on some of the current injection therapies and suggest possible improvements to methodological structure to inspire readers strive for high quality data. Further, through an example of a possible novel therapy, Actovegin, this editorial will hopefully challenge readers’ way of thinking to consider the reapplication of established drugs; posing the question can you teach an old drug new tricks?

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Osteoarthritis; Prolotherapy; Injections; Actovegin;Steroid; HA
Publisher:	Omics Publisher Group
ISSN:	2167-7921
Date of First Compliant Deposit:	9 December 2016
Date of Acceptance:	29 June 2016
Last Modified:	16 May 2023 17:31
URI:	https://orca.cardiff.ac.uk/id/eprint/96371

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