Laboratory evaluation of a novel anaesthesia delivery device

Paul, Alison ORCID: https://orcid.org/0000-0002-7653-9964, Clark, J. N., Salama, I. E., Jenkins, B. J., Goodwin, N., Wilkes, A. R., Mahoney, P. F. and Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 2017. Laboratory evaluation of a novel anaesthesia delivery device. Anaesthesia 72 (1) , pp. 63-72. 10.1111/anae.13625

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Abstract

Here, we describe proof of concept of a novel method for delivering volatile anaesthetics, where the liquid anaesthetic (sevoflurane or isoflurane) is formulated into an emulsion that is contained in a compact, lightweight device through which carrier gas flows. Release of anaesthetic is achieved by stirring of the formulation, allowing controlled and responsive release of anaesthetic at a variety of fixed flow rates between 0.5 l.min−1 and 5 l.min−1, with ventilated, non-ventilated and draw-over breathing systems. Anaesthetic release was evaluated using target anaesthetic concentrations ranging from 0.5% v/v to 8% v/v to mimic those typically required for induction and maintenance of anaesthesia, and lower concentrations suitable for sedation. Under all conditions, output could be maintained within 0.1% v/v of the intended setting, and the device could deliver a controlled level of anaesthetic for at least 60 min, with compensation for different ambient temperatures (10–30 °C) and carrier gas flow rates. This device offers a simple, inexpensive method of delivering safe concentrations of volatile anaesthetics for a wide range of applications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Medicine
Subjects:	Q Science > QD Chemistry R Medicine > RD Surgery
Uncontrolled Keywords:	anaesthetic delivery device; vapouriser; volatile anaesthetic agent
Publisher:	Wiley-Blackwell
ISSN:	0003-2409
Date of First Compliant Deposit:	30 November 2016
Date of Acceptance:	8 July 2016
Last Modified:	07 Nov 2023 04:22
URI:	https://orca.cardiff.ac.uk/id/eprint/96503

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