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Laboratory evaluation of a novel anaesthesia delivery device

Paul, Alison, Clark, J. N., Salama, I. E., Jenkins, B. J., Goodwin, N., Wilkes, A. R., Mahoney, P. F. and Hall, Judith Elizabeth 2017. Laboratory evaluation of a novel anaesthesia delivery device. Anaesthesia 72 (1) , pp. 63-72. 10.1111/anae.13625

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Here, we describe proof of concept of a novel method for delivering volatile anaesthetics, where the liquid anaesthetic (sevoflurane or isoflurane) is formulated into an emulsion that is contained in a compact, lightweight device through which carrier gas flows. Release of anaesthetic is achieved by stirring of the formulation, allowing controlled and responsive release of anaesthetic at a variety of fixed flow rates between 0.5 l.min−1 and 5 l.min−1, with ventilated, non-ventilated and draw-over breathing systems. Anaesthetic release was evaluated using target anaesthetic concentrations ranging from 0.5% v/v to 8% v/v to mimic those typically required for induction and maintenance of anaesthesia, and lower concentrations suitable for sedation. Under all conditions, output could be maintained within 0.1% v/v of the intended setting, and the device could deliver a controlled level of anaesthetic for at least 60 min, with compensation for different ambient temperatures (10–30 °C) and carrier gas flow rates. This device offers a simple, inexpensive method of delivering safe concentrations of volatile anaesthetics for a wide range of applications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RD Surgery
Uncontrolled Keywords: anaesthetic delivery device; vapouriser; volatile anaesthetic agent
Publisher: Wiley-Blackwell
ISSN: 0003-2409
Date of First Compliant Deposit: 30 November 2016
Date of Acceptance: 8 July 2016
Last Modified: 29 Jun 2019 16:24

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