The chimpanzee genome project

Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484 and Kehrer-Sawatzki, Hildegard 2008. The chimpanzee genome project. eLS 10.1002/9780470015902.a0020753

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Abstract

In 2005, a draft genome sequence of the common chimpanzee (Pan troglodytes) was published by the Chimpanzee Sequencing & Analysis Consortium (CSAC). This sequence has allowed us to catalogue the genetic differences which have accumulated since humans and chimpanzees diverged from their common ancestor 5–7 million years ago. These differences include approximately 35 million single-nucleotide substitutions and 5 million insertion/deletion events within the alignable regions. This catalogue of differences has been used to assess the magnitude and regional variation of the mutational forces which have shaped the two genomes, and to measure the strength of positive and negative selection acting on their genes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QL Zoology
Uncontrolled Keywords:	chimpanzee genome sequencing; polymorphism; nucleotide divergence; positive selection; rapid evolution; human–chimpanzee differences
Publisher:	Wiley-Blackwell
Last Modified:	02 Nov 2022 09:59
URI:	https://orca.cardiff.ac.uk/id/eprint/97067

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