Phosphoramidate Prodrugs Deliver with Potency Against Hepatitis C Virus

Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513 2010. Phosphoramidate Prodrugs Deliver with Potency Against Hepatitis C Virus. ChemMedChem 5 (11) , pp. 1841-1842. 10.1002/cmdc.201000310

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Abstract

original image INX-08189: A new sensation! The hepatitis C virus (HCV) antiviral clinical candidate INX-08189, which is a phosphoramidate prodrug of 2′-C-methylguanosine, has recently entered human clinical trials. This anti-HCV nucleoside-derived phosphoramidate, the third of its kind currently under clinical evaluation, has an impressive overall pharmacological profile and synergistic efficacy with other antiviral agents, and its development is highlighted here.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Wiley
ISSN:	1860-7179
Last Modified:	02 Nov 2022 10:03
URI:	https://orca.cardiff.ac.uk/id/eprint/97279

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