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Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial

Neal, Richard D., Barham, Allan, Bongard, Emily, Tudor Edwards, Rhiannon, Fitzgibbon, Jim, Griffiths, Gareth, Hamilton, Willie, Hood, Kerenza ORCID:, Nelson, Annmarie ORCID:, Parker, David, Porter, Cath ORCID:, Prout, Hayley ORCID:, Roberts, Kirsty, Rogers, Trevor, Thomas-Jones, Emma, Tod, Angela, Yeo, Seow Tien and Hurt, Chris N. ORCID: 2017. Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial. British Journal of Cancer 116 (3) , pp. 293-302. 10.1038/bjc.2016.414

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Background: Achieving earlier stage diagnosis is one option for improving lung cancer outcomes in the United Kingdom. Patients with lung cancer typically present with symptoms to general practitioners several times before referral or investigation. Methods: We undertook a mixed methods feasibility individually randomised controlled trial (the ELCID trial) to assess the feasibility and inform the design of a definitive, fully powered, UK-wide, Phase III trial of lowering the threshold for urgent investigation of suspected lung cancer. Patients over 60, with a smoking history, presenting with new chest symptoms to primary care, were eligible to be randomised to intervention (urgent chest X-ray) or usual care. Results: The trial design and materials were acceptable to GPs and patients. We randomised 255 patients from 22 practices, although the proportion of eligible patients who participated was lower than expected. Survey responses (89%), and the fidelity of the intervention (82% patients X-rayed within 3 weeks) were good. There was slightly higher anxiety and depression in the control arm in participants aged 475. Three patients (1.2%) were diagnosed with lung cancer. Conclusions: We have demonstrated the feasibility of individually randomising patients at higher risk of lung cancer, to a trial offering urgent investigation or usual care.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: lung cancer; early diagnosis; health economics; chest X-ray; NICE; RCT; symptoms; cough
Publisher: Springer Nature
ISSN: 0007-0920
Funders: NAEDI
Date of First Compliant Deposit: 17 January 2017
Date of Acceptance: 16 November 2016
Last Modified: 20 Sep 2023 22:00

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