On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier

Dutzan, Nicolas, Abusleme, Loreto, Bridgeman, Hayley, Greenwell-Wild, Teresa, Zangerle-Murray, Tamsin, Fife, Mark E., Bouladoux, Nicolas, Linley, Holly, Brenchley, Laura, Wemys, Kelly, Calderon, Gloria, Hong, Bo-Young, Break, Timothy J., Bowdish, Dawn M. E., Lionakis, Michail S., Jones, Simon A., Trinchieri, Giorgio, Diaz, Patricia I., Belkaid, Yasmine and Konkel, Joanne E. 2017. On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier. Immunity 46 (1) , pp. 133-147. 10.1016/j.immuni.2016.12.010

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Abstract

Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization- independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	mucosal immunology; Th17 cells; IL-17; oral immunity; barrier immunity; periodontitis; T cells
Additional Information:	This is an open access article under the terms of the CC-BY license.
Publisher:	Elsevier (Cell Press)
ISSN:	1074-7613
Related URLs:	http://www.cell.com/immunity/pdf/S1074-7...
Date of First Compliant Deposit:	23 January 2017
Date of Acceptance:	27 October 2016
Last Modified:	20 Jan 2021 09:30
URI:	https://orca.cardiff.ac.uk/id/eprint/97500

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