Dutzan, Nicolas, Abusleme, Loreto, Bridgeman, Hayley, Greenwell-Wild, Teresa, Zangerle-Murray, Tamsin, Fife, Mark E., Bouladoux, Nicolas, Linley, Holly, Brenchley, Laura, Wemys, Kelly, Calderon, Gloria, Hong, Bo-Young, Break, Timothy J., Bowdish, Dawn M. E., Lionakis, Michail S., Jones, Simon A.  ORCID: https://orcid.org/0000-0001-7297-9711, Trinchieri, Giorgio, Diaz, Patricia I., Belkaid, Yasmine and Konkel, Joanne E.
2017.
On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier.
Immunity
46
(1)
, pp. 133-147.
10.1016/j.immuni.2016.12.010
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Abstract
Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization- independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | mucosal immunology; Th17 cells; IL-17; oral immunity; barrier immunity; periodontitis; T cells |
| Additional Information: | This is an open access article under the terms of the CC-BY license. |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 1074-7613 |
| Related URLs: | |
| Date of First Compliant Deposit: | 23 January 2017 |
| Date of Acceptance: | 27 October 2016 |
| Last Modified: | 04 May 2023 20:08 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/97500 |
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